Justin Turner and Yasmani Grandal belted a pair of homers out of the park in the sixth and fourth innings, and rookie shortstop Corey Seager first put the Dodgers on the board with a two-out RBI single in the third.
Cubs right-handed ace Jake Arrieta sat after throwing 83 pitches and surrendering four runs on six hits in just five innings. Dodgers left-hander Rich Hill recorded six shutout innings and surrendered two hits on 93 pitches.
The best-of-seven series is tied 1-1 following a split at Wrigley Field.
Kenley Jansen is set to face Ben Zobrist, Anthony Rizzo and Javier Baez in the top of the ninth.
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